郭兴荣

姓名

郭兴荣

出生年月

1979年12月

单位

湖北医药学院基础医学院/附属太和医院

所属学科

基础医学-病理和病理生理学

职称、职务

副教授，硕士研究生导师

E-mail

4178206@qq.com

研究方向

1.代谢紊乱诱发糖尿病、非酒精性脂肪肝、肿瘤等慢性疾病的发病机制

2.干细胞治疗慢性代谢疾病临床应用研究

个人简介

郭兴荣，女，1979年12月生，博士，副教授，硕士研究生导师，湖北医药学院附属太和医院生命科学研究所副所长；胚胎干细胞研究湖北省重点实验室副主任；湖北医药学院生物医药研究院独立PI。从事代谢紊乱诱发糖尿病、非酒精性脂肪肝、肿瘤等慢性疾病的发病机制及干细胞临床治疗应用研究方向的研究工作。主持完成科研项目20余项，其中国家自然科学基金项目3项。发表论文20余篇，其中第一作者或通讯作者SCI收录论文12篇。主持获得湖北省科学技术进步奖三等奖1项。

代表作

1. Yulin He^#,  Xingrong Guo^#, Tingyu Lan, Jianbo Xia, Jinsong Wang,  Bei Li, Chunyan Peng,Yue Chen, Xiang Hu* and Zhongji Meng*, Human umbilical  cord-derived mesenchymal stem cells improve the function of liver in rats  with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3  signaling.Stem Cell Research & Therapy, 2021, 12:396.

2. Xingrong Guo^#*,  Meng Ye Shan#, Yu Huang, Zong Li Zhang, Yue Yuan, Long Jun Dai, Jue Wang, Xue  Peng Zhou, Fu Yun Ji, Jun Ming Tang, Zhong Ji Meng, Xu Zhi  Ruan*,BARMR1-mediated sorafenib resistance is derived through stem-like  property acquisition by activating integrin-FAK signaling pathways, Signal  Transduction and Targeted Therapy,2020, 5:97.

3. Zongli Zhang^#,  Haiqing Wu ^#, Longjun Dai, Yue Yuan , Yanshan Zhu ，Zhipeng Ma, Xuzhi  Ruan*, Xingrong Guo* ANGPTL8 enhances insulin sensitivity by  directly activating insulin-mediated AKT phosphorylation, Gene, 2020, 749,  (7)30.

4. Xingrong  Guo*^#,Mu-Yu Wu^# ,Long-Jun Dai ,Yu Huang,Meng-Ye  Shan ,Shi-Nan Ma ,Jue Wang ,Hao Peng , Yan Ding ,Qiu-Fang Zhang ,Jun-Ming  Tang ,Xu-Zhi Ruan* ,Dong-Sheng Li*. Nuclear FAM289-Galectin-1 interaction  controls FAM289-mediated tumor promotion in malignant glioma.J Exp Clin  Cancer Res.2019 38(1):394.

5. Hui Gui^#,  Xingrong Guo#, Juan Fang, Shi-Nan Ma, Gao Wu, Han-Jun Tu, Dong  Sheng Li, Long-Jun Dai, and Xu-Zhi Ruan, The Tumor-promoting Effects of  FAM92A1-289 in Cervical Carcinoma Cells. Anticancer Research .2016, 36:  5197-5204

6. Xingrong Guo,  XiaoLi Wang, YunChen, YaHong Yuan, YongMei Chen, YanDing, JuanFang, LiuJiao  Bian*,DongSheng Li*.ANGPTL8/betatrophin alleviates insulin resistance via the  Akt-GSK3 β or Akt-FoxO1 pathway in HepG2 cells.Experimental Cell Research,  2016，345：158–167

7. Xingrong Guo,Xiao Li  Wang, Man Chol Li, Ya Hong Yuan, Yun Chen, Dan Dan Zou, Liu Jiao Bian*,Dong  Sheng Li*, PDX-1 mRNA-induced reprogramming  of  mouse pancreas-derived mesenchymal  stem cells into  insulin-producing cells in vitro. Clin Exp Med. 2016,  15(4):501-9.