刘志新-湖北医药学院基础医学院

导师简介

姓名	刘志新
出生年月	1984年3月
单位	湖北医药学院基础医学院
所属学科	临床医学-医学微生物-医学病毒学
职称、职务	副教授，硕士研究生导师，
E-mail	lzx20022456@126.com
研究方向	1. 病毒感染与免疫 2. 病毒感染与肿瘤发生
个人简介	刘志新，男，1984年3月生，病毒学国家重点实验室博士后，病毒学十堰市重点实验室主任，湖北医药学院病毒学研究所所长，湖北医药学院基础医学院病原生物学教研室主任，湖北医药学院首席研究员（PI），《湖北医药学院学报》编委，硕士研究生导师。主要学术研究领域为病毒感染与免疫，发表论文20余篇，最高单篇影响因子为12.7，最高单篇他引次数已达700余次。主持国家自然科学基金、湖北省自然科学基金重点研发专项等科研项目10余项。获第三届全国基础医学青年教师讲课大赛一等奖、第九届全国医学院校青年教师教学基本功比赛二等奖、湖北省事业单位立功奖励、湖北医药学院五一劳动奖章。是湖北省科技厅权威专家库入库专家，武当人才卡金卡持有者，十堰市医学会病毒分会委员，十堰市医学会肝病分会常务委员。入选省级相关人才计划。
代表作（五年内）	1. Huang YP, Huang CC, Chen JK, Chen SW, Li B, Li J, Jin ZX, Zhang QW, Pan P, Du WX, Liu L, Liu ZX. Inhibition of SARS-CoV-2 replication by a ssDNA aptamer targeting the nucleocapsid protein. Microbiology Spectrum, 2024: e03410-23. 2. Huang CC, Yin YP, Pan P, Huang YP, Chen SW, Chen JK, Wang J, Xu G, Tao X, Xiao X, Li J, Yang J, Jin ZX, Li B, Tong ZH, Du WX, Liu L, Liu ZX. The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. Viruses, 2023, 15: 2304. 3. Liu ZX, Fu YN, Huang YP, Zeng F, RJJ, Xiao X, Sun XG, Jin H, Li J, Yang J, Du WX, Liu L. Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress, Microbiology Spectrum, 2022, 10(6): e0150922. 4. Liu L, Huang YP, Fu YN, Rao JJ, Zeng F, Ji MS, Xu X, Zhu JY, Du WX, Liu ZX. Hepatitis B virus promotes hepatocellular carcinoma development by activating GP73 to repress the innate immune response. Infectious agents and cancer. 2022. 17(1):52. 5. Yang R, Zhao Q, Rao J, Zeng F, Yuan S, Ji M, Sun X, Li J, Yang J, Jin Z, Liu L, Liu ZX. SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells. Frontiers in Microbiology. 2021. 12:654709. 6. Liu L, Zhu JY, Yang J, Li XH, Yuan J, Wu JG, Liu ZX. GP73facilitates hepatitis B virus replication by repressing the NF‐κB signaling pathway. Journal of Medical Virology. 2020. 92: 3327-3335. 7. Liu ZX, Xiao X, Wei XL, Li J, Yang J, Tan HB, Zhu JY, Zhang QW, Wu JG, Liu L. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. Journal of Medical Virology. 2020. 92(6):595-601. 8. Yu CF, Wei XL, Wang ZH, Liu L, Liu ZX, Liu J, Wu LL, Guo HL, Jin ZX. (2020). Occurrence of two NDM-1-producing Raoultella ornithinolytica and Enterobacter cloacae in a single patient in China: probable a novel antimicrobial resistance plasmid transfer in vivo by conjugation. Journal of global antimicrobial resistance, 2020. 22: 835–841. 9. Liu ZX,* Dai XC, Wang TC, Zhang CC, Zhang WJ, Zhang W, Zhang Q, Wu KL, Liu F, Liu YL, Wu JG. Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Cancer Letters. 2017. 400:149-160.